High human cytomegalovirus pp65 level in cardiac allografts precedes acute rejection episodes

High human cytomegalovirus pp65 level in cardiac allografts precedes acute rejection episodes

Cytomegalovirus (CMV) infection is a risk factor for acute and chronic rejection of transplanted organs. We evaluated, using immunohistochemistry, the presence of CMV pp65 matrix protein in cardiac allografts and its association with acute rejection. CMV pp65 was found in 83/88 (94%) endomyocardial biopsies obtained from 35 patients and the presence of CMV was confirmed in selected patients by ...

Serial measurement of integrated ultrasonic backscatter in human cardiac allografts for the recognition of acute rejection.

Cyclic variation of integrated ultrasonic backscatter (IB) was noninvasively measured in the septum and left ventricular posterior wall using a quantitative IB imaging system to assess the alterations in the acoustic properties of myocardium associated with acute cardiac allograft rejection. The study population consisted of 23 cardiac allograft recipients and 18 normal subjects. In each cardia...

Reversal of acute rejection episodes by deoxyspergualin (NKT-01) in dogs receiving renal allografts.

the preventive effect of NKT-01on the rejection of renal allografts in dogs, and suggested that NKT-01 maybe useful in clinical organ transplantation.70 In this study we have explored the efficacy of NKT-01 in treating acute rejection episodes in dogs receiving renal allografts. Unrelated outbred beagle dogs were used for the experiment. Renal allografting was performed as previously described....

cytomegalovirus and acute rejection in kidney transplantation

Accelerated rejection of murine cardiac allografts by murine cytomegalovirus-infected recipients. Lack of haplotype specificity.

Clinical studies have revealed a correlation between cytomegalovirus (CMV) infection and acute allograft rejection. Likewise, for a murine model we observed that C3H (H-2k) recipients infected with murine CMV (MCMV) rejected BALB/c (H-2d) cardiac allografts earlier than uninfected recipients (6.9 +/- 0.1 d compared with 8.1 +/- 0.6 d; P < 0.001). It has been hypothesized that MCMV epitopes cros...